The mission of AFSOUTH is to conduct Air Force, joint and combined air and space operations in addition to information operations in the USSOUTHCOM Area of Responsibility (AOR). To fulfill these responsibilities AFSOUTH employs a full spectrum of Intelligence, Surveillance and Reconnaissance (ISR), intra-theatre airlift and information assets. In addition the CAOC staff is responsible for developing strategy and plans to execute air and space operations in support of USSOUTHCOM objectives. The CAOC also provides command and control of all air and space assets in the AOR.
AFSOUTH oversees Air Force assets, five forward operating locations, and civil and military engagements in the USSOUTHCOM area of responsibility – Central and South America, and the Caribbean. AFSOUTH is also responsible for the combat readiness of one of five Falconer CAOC weapons systems in the Air Force.